Archive for the ‘mTOR Research’ Category

Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes.

Thursday, April 15th, 2010

Related Articles Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med. 2010 Mar 26; Authors: Ost A, Svensson K, Ruishalme ...

The mTOR Pathway: A New Target in Cancer Therapy.

Thursday, April 15th, 2010

Related Articles The mTOR Pathway: A New Target in Cancer Therapy. Curr Cancer Drug Targets. 2010 Apr 12; Authors: Ciuffreda L, Di Sanza C, Milella M ...

Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.

Thursday, April 15th, 2010

Related Articles Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells. Matrix Biol. 2010 Apr 9; ...

Building on a Foundation of VEGF and mTOR Targeted Agents in Renal Cell Carcinoma.

Wednesday, April 14th, 2010

Related Articles Building on a Foundation of VEGF and mTOR Targeted Agents in Renal Cell Carcinoma. Biochem Pharmacol. 2010 Apr 8; Authors: Flaherty KT, Puzanov I ...

Essential amino acids improve insulin activation of AKT/MTOR signaling in soleus muscle of aged rats.

Sunday, April 11th, 2010

Related Articles Essential amino acids improve insulin activation of AKT/MTOR signaling in soleus muscle of aged rats. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):81-9 Authors: Flati V, Caliaro F, ...

Suppressor of Cytokine Signaling 3 (SOCS3) Suppresses Hepatitis C Virus Replication in an mTOR-dependent Manner.

Saturday, April 10th, 2010

Related Articles Suppressor of Cytokine Signaling 3 (SOCS3) Suppresses Hepatitis C Virus Replication in an mTOR-dependent Manner. J Virol. 2010 Apr 7; Authors: Shao RX, Zhang L, Peng ...

Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

Saturday, April 10th, 2010

Related Articles Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR. Am J Physiol Cell Physiol. 2010 Apr 7; Authors: Wagner RJ, Martin KA, Powell RJ, Rzucidlo ...

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer’s disease.

Saturday, April 10th, 2010

Related Articles Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010;5(4):e9979 Authors: Spilman P, ...

IGFBP-2 expression in MCF-7 cells is regulated by the PI3K/AKT/mTOR pathway through Sp1-induced increase in transcription.

Friday, April 9th, 2010

Related Articles IGFBP-2 expression in MCF-7 cells is regulated by the PI3K/AKT/mTOR pathway through Sp1-induced increase in transcription. Growth Factors. 2010 Apr 7; Authors: Mireuta M, Darnel A, ...

Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death.

Friday, April 9th, 2010

Related Articles Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death. J Toxicol Sci. 2010;35(2):245-51 Authors: Nakatsu Y, Kotake Y, Takai N, ...

Reduced mortality and moderate alcohol consumption: The phospholipase D-mTOR connection.

Friday, April 9th, 2010

Related Articles Reduced mortality and moderate alcohol consumption: The phospholipase D-mTOR connection. Cell Cycle. 2010 Apr 5;9(7) Authors: Foster DA Many ...

Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation.

Friday, April 9th, 2010

Related Articles Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation. Oncol Rep. 2010 May;23(5):1443-7 Authors: Zhao N, Guo Y, Zhang M, Lin L, Zheng Z ...

Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells.

Thursday, April 8th, 2010

Related Articles Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells. Autophagy. 2010 May 2;6(4) Authors: Sini P, ...

EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mTOR activation.

Sunday, April 4th, 2010

Related Articles EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mTOR activation. J Biol Chem. 2010 Apr 1; Authors: Faoro ...

Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes, Limitations, and Further Proposals.

Sunday, April 4th, 2010

Related Articles Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes, Limitations, and Further Proposals. Transl Oncol. 2010 Apr;3(2):65-79 Authors: O'Reilly T, McSheehy PM ...

Compensatory activation of Akt in response to mTOR and Raf inhibitors – A rationale for dual-targeted therapy approaches in neuroendocrine tumor disease.

Saturday, April 3rd, 2010

Related Articles Compensatory activation of Akt in response to mTOR and Raf inhibitors - A rationale for dual-targeted therapy approaches in neuroendocrine tumor disease. Cancer Lett. 2010 Mar 29; ...

Energy Balance, the PI3K-AKT-mTOR Pathway Genes, and the Risk of Bladder Cancer.

Friday, April 2nd, 2010

Related Articles Energy Balance, the PI3K-AKT-mTOR Pathway Genes, and the Risk of Bladder Cancer. Cancer Prev Res (Phila Pa). 2010 Mar 30; Authors: Lin J, Wang J, Greisinger ...

mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?

Thursday, April 1st, 2010

Related Articles mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus? Discov Med. 2010 Mar;9(46):173-8 Authors: Fernandez D, Perl A ...

mTOR goes to the nucleus.

Wednesday, March 31st, 2010

Related Articles mTOR goes to the nucleus. Cell Cycle. 2010 Mar 1;9(5) Authors: Jiang Y ...

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor.

Wednesday, March 31st, 2010

Related Articles Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg Med Chem Lett. 2010 Mar 12; Authors: Heffron TP, Berry M, Castanedo G, Chang ...